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Fatty Acid Desaturation Links Germ Cell Loss to Longevity Through NHR-80/HNF4 in C. elegans

BACKGROUND: Preventing germline stem cell proliferation extends lifespan in nematodes and flies. So far, studies on germline-longevity signaling have focused on daf-16/FOXO and daf-12/VDR. Here, we report on NHR-80/HNF4, a nuclear receptor that specifically mediates longevity induced by depletion of...

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Detalles Bibliográficos
Autores principales:	Goudeau, Jérôme, Bellemin, Stéphanie, Toselli-Mollereau, Esther, Shamalnasab, Mehrnaz, Chen, Yiqun, Aguilaniu, Hugo
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3057950/ https://www.ncbi.nlm.nih.gov/pubmed/21423649 http://dx.doi.org/10.1371/journal.pbio.1000599

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