mRNA Display Selection of an Optimized MDM2-Binding Peptide That Potently Inhibits MDM2-p53 Interaction

p53 is a tumor suppressor protein that prevents tumorigenesis through cell cycle arrest or apoptosis of cells in response to cellular stress such as DNA damage. Because the oncoprotein MDM2 interacts with p53 and inhibits its activity, MDM2-p53 interaction has been a major target for the development...

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Detalles Bibliográficos
Autores principales: Shiheido, Hirokazu, Takashima, Hideaki, Doi, Nobuhide, Yanagawa, Hiroshi
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3057987/
https://www.ncbi.nlm.nih.gov/pubmed/21423613
http://dx.doi.org/10.1371/journal.pone.0017898

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3057987/
https://www.ncbi.nlm.nih.gov/pubmed/21423613
http://dx.doi.org/10.1371/journal.pone.0017898

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