Hypomethylation of Intragenic LINE-1 Represses Transcription in Cancer Cells through AGO2

In human cancers, the methylation of long interspersed nuclear element -1 (LINE-1 or L1) retrotransposons is reduced. This occurs within the context of genome wide hypomethylation, and although it is common, its role is poorly understood. L1s are widely distributed both inside and outside of genes,...

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Detalles Bibliográficos
Autores principales: Aporntewan, Chatchawit, Phokaew, Chureerat, Piriyapongsa, Jittima, Ngamphiw, Chumpol, Ittiwut, Chupong, Tongsima, Sissades, Mutirangura, Apiwat
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3057998/
https://www.ncbi.nlm.nih.gov/pubmed/21423624
http://dx.doi.org/10.1371/journal.pone.0017934

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3057998/
https://www.ncbi.nlm.nih.gov/pubmed/21423624
http://dx.doi.org/10.1371/journal.pone.0017934

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