TRPM8 and Na(v)1.8 sodium channels are required for transthyretin-induced calcium influx in growth cones of small-diameter TrkA-positive sensory neurons

BACKGROUND: Familial amyloidotic polyneuropathy (FAP) is a peripheral neuropathy caused by the extracellular accumulation and deposition of insoluble transthyretin (TTR) aggregates. However the molecular mechanism that underlies TTR toxicity in peripheral nerves is unclear. Previous studies have sug...

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Detalles Bibliográficos
Autores principales: Gasperini, Robert J, Hou, Xu, Parkington, Helena, Coleman, Harry, Klaver, David W, Vincent, Adele J, Foa, Lisa C, Small, David H
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3058062/
https://www.ncbi.nlm.nih.gov/pubmed/21375738
http://dx.doi.org/10.1186/1750-1326-6-19

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3058062/
https://www.ncbi.nlm.nih.gov/pubmed/21375738
http://dx.doi.org/10.1186/1750-1326-6-19

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