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TRPM8 and Na(v)1.8 sodium channels are required for transthyretin-induced calcium influx in growth cones of small-diameter TrkA-positive sensory neurons
BACKGROUND: Familial amyloidotic polyneuropathy (FAP) is a peripheral neuropathy caused by the extracellular accumulation and deposition of insoluble transthyretin (TTR) aggregates. However the molecular mechanism that underlies TTR toxicity in peripheral nerves is unclear. Previous studies have sug...
Autores principales: | Gasperini, Robert J, Hou, Xu, Parkington, Helena, Coleman, Harry, Klaver, David W, Vincent, Adele J, Foa, Lisa C, Small, David H |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3058062/ https://www.ncbi.nlm.nih.gov/pubmed/21375738 http://dx.doi.org/10.1186/1750-1326-6-19 |
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