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Haploinsufficiency and the sex chromosomes from yeasts to humans
BACKGROUND: Haploinsufficient (HI) genes are those for which a reduction in copy number in a diploid from two to one results in significantly reduced fitness. Haploinsufficiency is increasingly implicated in human disease, and so predicting this phenotype could provide insights into the genetic mech...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2011
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3058074/ https://www.ncbi.nlm.nih.gov/pubmed/21356089 http://dx.doi.org/10.1186/1741-7007-9-15 |