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Crystal structure of XMRV protease differs from the structures of other retropepsins

Using energy and density guided Rosetta refinement to improve molecular replacement, we have determined the crystal structure of the protease (PR) encoded by xenotropic murine leukemia virus-related virus (XMRV). Despite overall similarity of XMRV PR to other retropepsins, the topology of its dimer...

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Detalles Bibliográficos
Autores principales: Li, Mi, DiMaio, Frank, Zhou, Dongwen, Gustchina, Alla, Lubkowski, Jacek, Dauter, Zbigniew, Baker, David, Wlodawer, Alexander
Formato: Texto
Lenguaje:English
Publicado: 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3058223/
https://www.ncbi.nlm.nih.gov/pubmed/21258323
http://dx.doi.org/10.1038/nsmb.1964