Structure of a nanobody-stabilized active state of the β(2) adrenoceptor

G protein coupled receptors (GPCRs) exhibit a spectrum of functional behaviors in response to natural and synthetic ligands. Recent crystal structures provide insights into inactive states of several GPCRs. Efforts to obtain an agonist-bound active-state GPCR structure have proven difficult due to t...

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Detalles Bibliográficos
Autores principales: Rasmussen, Søren G. F., Choi, Hee-Jung, Fung, Juan Jose, Pardon, Els, Casarosa, Paola, Chae, Pil Seok, DeVree, Brian T., Rosenbaum, Daniel M., Thian, Foon Sun, Kobilka, Tong Sun, Schnapp, Andreas, Konetzki, Ingo, Sunahara, Roger K., Gellman, Samuel H., Pautsch, Alexander, Steyaert, Jan, Weis, William I., Kobilka, Brian K.
Formato: Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3058308/
https://www.ncbi.nlm.nih.gov/pubmed/21228869
http://dx.doi.org/10.1038/nature09648

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3058308/
https://www.ncbi.nlm.nih.gov/pubmed/21228869
http://dx.doi.org/10.1038/nature09648

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