The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance

The role of autophagy, a lysosomal degradation pathway which prevents cellular damage, in the maintenance of adult mouse hematopoietic stem cells (HSCs) remains unknown. Although normal HSCs sustain life-long hematopoiesis, malignant transformation of HSCs leads to leukemia. Therefore, mechanisms pr...

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Detalles Bibliográficos
Autores principales: Mortensen, Monika, Soilleux, Elizabeth J., Djordjevic, Gordana, Tripp, Rebecca, Lutteropp, Michael, Sadighi-Akha, Elham, Stranks, Amanda J., Glanville, Julie, Knight, Samantha, W. Jacobsen, Sten-Eirik, Kranc, Kamil R., Simon, Anna Katharina
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3058574/
https://www.ncbi.nlm.nih.gov/pubmed/21339326
http://dx.doi.org/10.1084/jem.20101145

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3058574/
https://www.ncbi.nlm.nih.gov/pubmed/21339326
http://dx.doi.org/10.1084/jem.20101145

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