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The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance

The role of autophagy, a lysosomal degradation pathway which prevents cellular damage, in the maintenance of adult mouse hematopoietic stem cells (HSCs) remains unknown. Although normal HSCs sustain life-long hematopoiesis, malignant transformation of HSCs leads to leukemia. Therefore, mechanisms pr...

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Detalles Bibliográficos
Autores principales:	Mortensen, Monika, Soilleux, Elizabeth J., Djordjevic, Gordana, Tripp, Rebecca, Lutteropp, Michael, Sadighi-Akha, Elham, Stranks, Amanda J., Glanville, Julie, Knight, Samantha, W. Jacobsen, Sten-Eirik, Kranc, Kamil R., Simon, Anna Katharina
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2011
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3058574/ https://www.ncbi.nlm.nih.gov/pubmed/21339326 http://dx.doi.org/10.1084/jem.20101145

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