An autoimmune-associated variant in PTPN2 reveals an impairment of IL-2R signaling in CD4(+) T cells

The IL-2/IL-2R signaling pathway plays an important role in autoimmunity. Several genes identified in GWA studies encode proteins in the IL-2/IL-2R signaling cascade that are associated with autoimmune diseases. One of these, PTPN2, encodes a protein tyrosine phosphatase that is highly expressed in...

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Detalles Bibliográficos
Autores principales: Long, S Alice, Cerosaletti, Karen, Wan, Jia Yin, Ho, Jhon-Chun, Tatum, Megan, Wei, Shan, Shilling, Heather G., Buckner, Jane H
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3058680/
https://www.ncbi.nlm.nih.gov/pubmed/21179116
http://dx.doi.org/10.1038/gene.2010.54

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3058680/
https://www.ncbi.nlm.nih.gov/pubmed/21179116
http://dx.doi.org/10.1038/gene.2010.54

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