2′-O methylation of the viral mRNA cap evades host restriction by IFIT family members

Cellular messenger RNA (mRNA) of higher eukaryotes and many viral RNAs are methylated at the N-7 and 2′-O positions of the 5′ guanosine cap by specific nuclear and cytoplasmic methyltransferases (MTases), respectively. Whereas N-7 methylation is essential for RNA translation and stability(1), the fu...

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Detalles Bibliográficos
Autores principales: Daffis, Stephane, Szretter, Kristy J., Schriewer, Jill, Li, Jianqing, Youn, Soonjeon, Errett, John, Lin, Tsai-Yu, Schneller, Stewart, Zust, Roland, Dong, Hongping, Thiel, Volker, Sen, Ganes C., Fensterl, Volker, Klimstra, William B., Pierson, Theodore C., Buller, R. Mark, Gale Jr, Michael, Shi, Pei-Yong, Diamond, Michael S.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3058805/
https://www.ncbi.nlm.nih.gov/pubmed/21085181
http://dx.doi.org/10.1038/nature09489

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3058805/
https://www.ncbi.nlm.nih.gov/pubmed/21085181
http://dx.doi.org/10.1038/nature09489

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