Membrane Topology of NAADP-sensitive Two-pore Channels and Their Regulation by N-linked Glycosylation

Two-pore channels (TPCs) localize to the endolysosomal system and have recently emerged as targets for the Ca(2+)-mobilizing messenger, nicotinic acid adenine dinucleotide phosphate (NAADP). However, their membrane topology is unknown. Using fluorescence protease protection assays, we show that huma...

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Detalles Bibliográficos
Autores principales: Hooper, Robert, Churamani, Dev, Brailoiu, Eugen, Taylor, Colin W., Patel, Sandip
Formato: Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2011
Materias:
Signal Transduction
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3059026/
https://www.ncbi.nlm.nih.gov/pubmed/21173144
http://dx.doi.org/10.1074/jbc.M110.189985

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3059026/
https://www.ncbi.nlm.nih.gov/pubmed/21173144
http://dx.doi.org/10.1074/jbc.M110.189985

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