Co-directional replication-transcription conflicts lead to replication restart

Head-on encounters between the replication and transcription machineries on the lagging DNA strand can lead to replication fork arrest and genomic instability1,2. To avoid head-on encounters, most genes, especially essential and highly transcribed genes, are encoded on the leading strand such that t...

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Detalles Bibliográficos
Autores principales: Merrikh, Houra, Machón, Cristina, Grainger, William H., Grossman, Alan D., Soultanas, Panos
Formato: Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3059490/
https://www.ncbi.nlm.nih.gov/pubmed/21350489
http://dx.doi.org/10.1038/nature09758

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3059490/
https://www.ncbi.nlm.nih.gov/pubmed/21350489
http://dx.doi.org/10.1038/nature09758

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