Effects of Anti-VEGF on Predicted Antibody Biodistribution: Roles of Vascular Volume, Interstitial Volume, and Blood Flow

BACKGROUND: The identification of clinically meaningful and predictive models of disposition kinetics for cancer therapeutics is an ongoing pursuit in drug development. In particular, the growing interest in preclinical evaluation of anti-angiogenic agents alone or in combination with other drugs re...

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Detalles Bibliográficos
Autores principales: Boswell, C. Andrew, Ferl, Gregory Z., Mundo, Eduardo E., Bumbaca, Daniela, Schweiger, Michelle G., Theil, Frank-Peter, Fielder, Paul J., Khawli, Leslie A.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3060062/
https://www.ncbi.nlm.nih.gov/pubmed/21436893
http://dx.doi.org/10.1371/journal.pone.0017874

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3060062/
https://www.ncbi.nlm.nih.gov/pubmed/21436893
http://dx.doi.org/10.1371/journal.pone.0017874

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