Dissecting the Metabolic Roles of Pteridine Reductase 1 in Trypanosoma brucei and Leishmania major

Leishmania parasites are pteridine auxotrophs that use an NADPH-dependent pteridine reductase 1 (PTR1) and NADH-dependent quinonoid dihydropteridine reductase (QDPR) to salvage and maintain intracellular pools of tetrahydrobiopterin (H(4)B). However, the African trypanosome lacks a credible candidat...

Descripción completa

Detalles Bibliográficos
Autores principales: Ong, Han B., Sienkiewicz, Natasha, Wyllie, Susan, Fairlamb, Alan H.
Formato: Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2011
Materias:
Enzymology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3060496/
https://www.ncbi.nlm.nih.gov/pubmed/21239486
http://dx.doi.org/10.1074/jbc.M110.209593

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3060496/
https://www.ncbi.nlm.nih.gov/pubmed/21239486
http://dx.doi.org/10.1074/jbc.M110.209593

Ejemplares similares