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Dissecting the Metabolic Roles of Pteridine Reductase 1 in Trypanosoma brucei and Leishmania major

Leishmania parasites are pteridine auxotrophs that use an NADPH-dependent pteridine reductase 1 (PTR1) and NADH-dependent quinonoid dihydropteridine reductase (QDPR) to salvage and maintain intracellular pools of tetrahydrobiopterin (H(4)B). However, the African trypanosome lacks a credible candidat...

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Detalles Bibliográficos
Autores principales:	Ong, Han B., Sienkiewicz, Natasha, Wyllie, Susan, Fairlamb, Alan H.
Formato:	Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2011
Materias:	Enzymology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3060496/ https://www.ncbi.nlm.nih.gov/pubmed/21239486 http://dx.doi.org/10.1074/jbc.M110.209593

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