Substrate docking to γ-secretase allows access of γ-secretase modulators to an allosteric site

γ-Secretase generates the peptides of Alzheimer's disease, Aβ(40) and Aβ(42), by cleaving the amyloid precursor protein within its transmembrane domain. γ-Secretase also cleaves numerous other substrates, raising concerns about γ-secretase inhibitor off-target effects. Another important class o...

Descripción completa

Detalles Bibliográficos
Autores principales: Uemura, Kengo, Farner, Katherine C., Hashimoto, Tadafumi, Nasser-Ghodsi, Navine, Wolfe, Michael S., Koo, Edward H., Hyman, Bradley T., Berezovska, Oksana
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3060602/
https://www.ncbi.nlm.nih.gov/pubmed/21119643
http://dx.doi.org/10.1038/ncomms1129

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3060602/
https://www.ncbi.nlm.nih.gov/pubmed/21119643
http://dx.doi.org/10.1038/ncomms1129

Ejemplares similares