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Substrate docking to γ-secretase allows access of γ-secretase modulators to an allosteric site

γ-Secretase generates the peptides of Alzheimer's disease, Aβ(40) and Aβ(42), by cleaving the amyloid precursor protein within its transmembrane domain. γ-Secretase also cleaves numerous other substrates, raising concerns about γ-secretase inhibitor off-target effects. Another important class o...

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Detalles Bibliográficos
Autores principales:	Uemura, Kengo, Farner, Katherine C., Hashimoto, Tadafumi, Nasser-Ghodsi, Navine, Wolfe, Michael S., Koo, Edward H., Hyman, Bradley T., Berezovska, Oksana
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2010
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3060602/ https://www.ncbi.nlm.nih.gov/pubmed/21119643 http://dx.doi.org/10.1038/ncomms1129

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