Deep resequencing reveals excess rare recent variants consistent with explosive population growth

Accurately determining the distribution of rare variants is an important goal of human genetics, but resequencing of a sample large enough for this purpose has been unfeasible until now. Here, we applied Sanger sequencing of genomic PCR amplicons to resequence the diabetes-associated genes KCNJ11 an...

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Detalles Bibliográficos
Autores principales: Coventry, Alex, Bull-Otterson, Lara M., Liu, Xiaoming, Clark, Andrew G., Maxwell, Taylor J., Crosby, Jacy, Hixson, James E., Rea, Thomas J., Muzny, Donna M., Lewis, Lora R., Wheeler, David A., Sabo, Aniko, Lusk, Christine, Weiss, Kenneth G., Akbar, Humeira, Cree, Andrew, Hawes, Alicia C., Newsham, Irene, Varghese, Robin T., Villasana, Donna, Gross, Shannon, Joshi, Vandita, Santibanez, Jireh, Morgan, Margaret, Chang, Kyle, IV, Walker Hale, Templeton, Alan R., Boerwinkle, Eric, Gibbs, Richard, Sing, Charles F.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3060603/
https://www.ncbi.nlm.nih.gov/pubmed/21119644
http://dx.doi.org/10.1038/ncomms1130

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3060603/
https://www.ncbi.nlm.nih.gov/pubmed/21119644
http://dx.doi.org/10.1038/ncomms1130

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