Selective Constraints on Amino Acids Estimated by a Mechanistic Codon Substitution Model with Multiple Nucleotide Changes

BACKGROUND: Empirical substitution matrices represent the average tendencies of substitutions over various protein families by sacrificing gene-level resolution. We develop a codon-based model, in which mutational tendencies of codon, a genetic code, and the strength of selective constraints against...

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Detalles Bibliográficos
Autor principal: Miyazawa, Sanzo
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3060808/
https://www.ncbi.nlm.nih.gov/pubmed/21445250
http://dx.doi.org/10.1371/journal.pone.0017244

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3060808/
https://www.ncbi.nlm.nih.gov/pubmed/21445250
http://dx.doi.org/10.1371/journal.pone.0017244

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