The Repetitive Oligopeptide Sequences Modulate Cytopathic Potency but Are Not Crucial for Cellular Uptake of Clostridium difficile Toxin A

The pathogenicity of Clostridium difficile is primarily linked to secretion of the intracellular acting toxins A (TcdA) and B (TcdB) which monoglucosylate and thereby inactivate Rho GTPases of host cells. Although the molecular mode of action of TcdA and TcdB is well understood, far less is known ab...

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Detalles Bibliográficos
Autores principales: Olling, Alexandra, Goy, Sebastian, Hoffmann, Florian, Tatge, Helma, Just, Ingo, Gerhard, Ralf
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3060812/
https://www.ncbi.nlm.nih.gov/pubmed/21445253
http://dx.doi.org/10.1371/journal.pone.0017623

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3060812/
https://www.ncbi.nlm.nih.gov/pubmed/21445253
http://dx.doi.org/10.1371/journal.pone.0017623

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