Minimizing the risk of hypoglycemia in patients with type 2 diabetes mellitus
Hypoglycemia is a major barrier to achieving glycemic goals in patients with diabetes. Both acute and chronically recurrent hypoglycemic events appear to have long-term consequences for patients with type 2 diabetes mellitus (T2DM). Chronically recurrent hypoglycemia may lead to an impairment of the...
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Formato: | Texto |
Lenguaje: | English |
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Dove Medical Press
2010
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3061431/ https://www.ncbi.nlm.nih.gov/pubmed/21437076 |
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author | Kushner, Pamela |
author_facet | Kushner, Pamela |
author_sort | Kushner, Pamela |
collection | PubMed |
description | Hypoglycemia is a major barrier to achieving glycemic goals in patients with diabetes. Both acute and chronically recurrent hypoglycemic events appear to have long-term consequences for patients with type 2 diabetes mellitus (T2DM). Chronically recurrent hypoglycemia may lead to an impairment of the counterregulatory system, with the potential for the development of hypoglycemia unawareness syndrome, increased severe hypoglycemia-associated hospitalization, and increased mortality. Hypoglycemic events may also have negative implications in cardiovascular disease and/or dementia. Avoidance of hypoglycemia by treating with appropriate, individualized regimens for patients with T2DM should be a primary focus of physicians. Utilizing traditional agents (eg, metformin and thiazolidinediones) that do not promote hypoglycemia, in combination with newer agents such as dipeptidyl peptidase-4 inhibitors and incretin mimetics, could offer a therapeutic advantage when trying to help patients reach their hemoglobin A(1c) goal without the added risk of hypoglycemia. |
format | Text |
id | pubmed-3061431 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-30614312011-03-23 Minimizing the risk of hypoglycemia in patients with type 2 diabetes mellitus Kushner, Pamela Diabetes Metab Syndr Obes Short Report Hypoglycemia is a major barrier to achieving glycemic goals in patients with diabetes. Both acute and chronically recurrent hypoglycemic events appear to have long-term consequences for patients with type 2 diabetes mellitus (T2DM). Chronically recurrent hypoglycemia may lead to an impairment of the counterregulatory system, with the potential for the development of hypoglycemia unawareness syndrome, increased severe hypoglycemia-associated hospitalization, and increased mortality. Hypoglycemic events may also have negative implications in cardiovascular disease and/or dementia. Avoidance of hypoglycemia by treating with appropriate, individualized regimens for patients with T2DM should be a primary focus of physicians. Utilizing traditional agents (eg, metformin and thiazolidinediones) that do not promote hypoglycemia, in combination with newer agents such as dipeptidyl peptidase-4 inhibitors and incretin mimetics, could offer a therapeutic advantage when trying to help patients reach their hemoglobin A(1c) goal without the added risk of hypoglycemia. Dove Medical Press 2010-04-13 /pmc/articles/PMC3061431/ /pubmed/21437076 Text en © 2010 Kushner, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited. |
spellingShingle | Short Report Kushner, Pamela Minimizing the risk of hypoglycemia in patients with type 2 diabetes mellitus |
title | Minimizing the risk of hypoglycemia in patients with type 2 diabetes mellitus |
title_full | Minimizing the risk of hypoglycemia in patients with type 2 diabetes mellitus |
title_fullStr | Minimizing the risk of hypoglycemia in patients with type 2 diabetes mellitus |
title_full_unstemmed | Minimizing the risk of hypoglycemia in patients with type 2 diabetes mellitus |
title_short | Minimizing the risk of hypoglycemia in patients with type 2 diabetes mellitus |
title_sort | minimizing the risk of hypoglycemia in patients with type 2 diabetes mellitus |
topic | Short Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3061431/ https://www.ncbi.nlm.nih.gov/pubmed/21437076 |
work_keys_str_mv | AT kushnerpamela minimizingtheriskofhypoglycemiainpatientswithtype2diabetesmellitus |