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Bistability, Probability Transition Rate and First-Passage Time in an Autoactivating Positive-Feedback Loop
A hallmark of positive-feedback regulation is bistability, which gives rise to distinct cellular states with high and low expression levels, and that stochasticity in gene expression can cause random transitions between two states, yielding bimodal population distribution (Kaern et al., 2005, Nat Re...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2011
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3061858/ https://www.ncbi.nlm.nih.gov/pubmed/21445288 http://dx.doi.org/10.1371/journal.pone.0017104 |