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Genetic Requirement for Mutagenesis of the G[8,5-Me]T Cross-Link in Escherichia coli: DNA Polymerases IV and V Compete for Error-Prone Bypass
[Image: see text] γ-Radiation generates a variety of complex lesions in DNA, including the G[8,5-Me]T intrastrand cross-link in which C8 of guanine is covalently linked to the 5-methyl group of the 3′-thymine. We have investigated the toxicity and mutagenesis of this lesion by replicating a G[8,5-Me...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2011
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3062377/ https://www.ncbi.nlm.nih.gov/pubmed/21302943 http://dx.doi.org/10.1021/bi102064z |