The Intracellular Threonine of Amyloid Precursor Protein That Is Essential for Docking of Pin1 Is Dispensable for Developmental Function

BACKGROUND: Processing of Aβ-precursor protein (APP) plays an important role in Alzheimer's Disease (AD) pathogenesis. Thr residue at amino acid 668 of the APP intracellular domain (AID) is highly conserved. When phosphorylated, this residue generates a binding site for Pin1. The interaction of...

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Detalles Bibliográficos
Autores principales: Barbagallo, Alessia P. M., Wang, Zilai, Zheng, Hui, D'Adamio, Luciano
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3062548/
https://www.ncbi.nlm.nih.gov/pubmed/21445342
http://dx.doi.org/10.1371/journal.pone.0018006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3062548/
https://www.ncbi.nlm.nih.gov/pubmed/21445342
http://dx.doi.org/10.1371/journal.pone.0018006

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