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How the biotin–streptavidin interaction was made even stronger: investigation via crystallography and a chimaeric tetramer
The interaction between SA (streptavidin) and biotin is one of the strongest non-covalent interactions in Nature. SA is a widely used tool and a paradigm for protein–ligand interactions. We previously developed a SA mutant, termed Tr (traptavidin), possessing a 10-fold lower off-rate for biotin, wit...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Portland Press Ltd.
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3062853/ https://www.ncbi.nlm.nih.gov/pubmed/21241253 http://dx.doi.org/10.1042/BJ20101593 |