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A two step synthesis of a key unit B precursor of cryptophycins by asymmetric hydrogenation

A novel highly enantioselective two step access to a unit B precursor of cryptophycins in good yields from commercially available starting materials has been developed. The key step is an asymmetric hydrogenation using the commercially available [(COD)Rh-(R,R)-Et-DuPhos]BF(4) catalyst. The synthetic...

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Detalles Bibliográficos
Autores principales: Sammet, Benedikt, Brax, Mathilde, Sewald, Norbert
Formato: Texto
Lenguaje:English
Publicado: Beilstein-Institut 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3063055/
https://www.ncbi.nlm.nih.gov/pubmed/21448253
http://dx.doi.org/10.3762/bjoc.7.32