Redox Regulation of Insulin Degradation by Insulin-Degrading Enzyme

Insulin-degrading enzyme (IDE) is a thiol sensitive peptidase that degrades insulin and amyloid β, and has been linked to type 2 diabetes mellitus and Alzheimer's disease. We examined the thiol sensitivity of IDE using S-nitrosoglutathione, reduced glutathione, and oxidized glutathione to disti...

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Detalles Bibliográficos
Autores principales: Cordes, Crystal M., Bennett, Robert G., Siford, Gerri L., Hamel, Frederick G.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3063182/
https://www.ncbi.nlm.nih.gov/pubmed/21448434
http://dx.doi.org/10.1371/journal.pone.0018138

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3063182/
https://www.ncbi.nlm.nih.gov/pubmed/21448434
http://dx.doi.org/10.1371/journal.pone.0018138

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