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Uncoupling Antisense-Mediated Silencing and DNA Methylation in the Imprinted Gnas Cluster
There is increasing evidence that non-coding macroRNAs are major elements for silencing imprinted genes, but their mechanism of action is poorly understood. Within the imprinted Gnas cluster on mouse chromosome 2, Nespas is a paternally expressed macroRNA that arises from an imprinting control regio...
Autores principales: | , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3063750/ https://www.ncbi.nlm.nih.gov/pubmed/21455290 http://dx.doi.org/10.1371/journal.pgen.1001347 |