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“Fluctuograms” Reveal the Intermittent Intra-Protein Communication in Subtilisin Carlsberg and Correlate Mechanical Coupling with Co-Evolution

The mechanism of intra-protein communication and allosteric coupling is key to understanding the structure-property relationship of protein function. For subtilisin Carlsberg, the Ca(2+)-binding loop is distal to substrate-binding and active sites, yet the serine protease function depends on Ca(2+)...

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Detalles Bibliográficos
Autores principales: Silvestre-Ryan, Jordi, Lin, Yuchun, Chu, Jhih-Wei
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3063751/
https://www.ncbi.nlm.nih.gov/pubmed/21455286
http://dx.doi.org/10.1371/journal.pcbi.1002023