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“Fluctuograms” Reveal the Intermittent Intra-Protein Communication in Subtilisin Carlsberg and Correlate Mechanical Coupling with Co-Evolution
The mechanism of intra-protein communication and allosteric coupling is key to understanding the structure-property relationship of protein function. For subtilisin Carlsberg, the Ca(2+)-binding loop is distal to substrate-binding and active sites, yet the serine protease function depends on Ca(2+)...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2011
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3063751/ https://www.ncbi.nlm.nih.gov/pubmed/21455286 http://dx.doi.org/10.1371/journal.pcbi.1002023 |