Small-Molecule Inhibitor Leads of Ribosome-Inactivating Proteins Developed Using the Doorstop Approach

Ribosome-inactivating proteins (RIPs) are toxic because they bind to 28S rRNA and depurinate a specific adenine residue from the α-sarcin/ricin loop (SRL), thereby inhibiting protein synthesis. Shiga-like toxins (Stx1 and Stx2), produced by Escherichia coli, are RIPs that cause outbreaks of foodborn...

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Detalles Bibliográficos
Autores principales: Pang, Yuan-Ping, Park, Jewn Giew, Wang, Shaohua, Vummenthala, Anuradha, Mishra, Rajesh K., McLaughlin, John E., Di, Rong, Kahn, Jennifer Nielsen, Tumer, Nilgun E., Janosi, Laszlo, Davis, Jon, Millard, Charles B.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3063779/
https://www.ncbi.nlm.nih.gov/pubmed/21455295
http://dx.doi.org/10.1371/journal.pone.0017883

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3063779/
https://www.ncbi.nlm.nih.gov/pubmed/21455295
http://dx.doi.org/10.1371/journal.pone.0017883

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