Phenobarbital Mediates an Epigenetic Switch at the Constitutive Androstane Receptor (CAR) Target Gene Cyp2b10 in the Liver of B6C3F1 Mice

Evidence suggests that epigenetic perturbations are involved in the adverse effects associated with some drugs and toxicants, including certain classes of non-genotoxic carcinogens. Such epigenetic changes (altered DNA methylation and covalent histone modifications) may take place at the earliest st...

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Detalles Bibliográficos
Autores principales: Lempiäinen, Harri, Müller, Arne, Brasa, Sarah, Teo, Soon-Siong, Roloff, Tim-Christoph, Morawiec, Laurent, Zamurovic, Natasa, Vicart, Axel, Funhoff, Enrico, Couttet, Philippe, Schübeler, Dirk, Grenet, Olivier, Marlowe, Jennifer, Moggs, Jonathan, Terranova, Rémi
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3063791/
https://www.ncbi.nlm.nih.gov/pubmed/21455306
http://dx.doi.org/10.1371/journal.pone.0018216

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3063791/
https://www.ncbi.nlm.nih.gov/pubmed/21455306
http://dx.doi.org/10.1371/journal.pone.0018216

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