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Phenobarbital Mediates an Epigenetic Switch at the Constitutive Androstane Receptor (CAR) Target Gene Cyp2b10 in the Liver of B6C3F1 Mice
Evidence suggests that epigenetic perturbations are involved in the adverse effects associated with some drugs and toxicants, including certain classes of non-genotoxic carcinogens. Such epigenetic changes (altered DNA methylation and covalent histone modifications) may take place at the earliest st...
Autores principales: | Lempiäinen, Harri, Müller, Arne, Brasa, Sarah, Teo, Soon-Siong, Roloff, Tim-Christoph, Morawiec, Laurent, Zamurovic, Natasa, Vicart, Axel, Funhoff, Enrico, Couttet, Philippe, Schübeler, Dirk, Grenet, Olivier, Marlowe, Jennifer, Moggs, Jonathan, Terranova, Rémi |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3063791/ https://www.ncbi.nlm.nih.gov/pubmed/21455306 http://dx.doi.org/10.1371/journal.pone.0018216 |
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