Premature death and neurologic abnormalities in transgenic mice expressing a mutant huntingtin exon-2 fragment

Huntington's disease (HD) is a fatal neurodegenerative disease characterized pathologically by aggregates composed of N-terminal fragments of the mutant form of the protein huntingtin (htt). The role of these N-terminal fragments in disease pathogenesis has been questioned based in part on stud...

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Detalles Bibliográficos
Autores principales: Tebbenkamp, Andrew T.N., Swing, Debbie, Tessarollo, Lino, Borchelt, David R.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3063989/
https://www.ncbi.nlm.nih.gov/pubmed/21307087
http://dx.doi.org/10.1093/hmg/ddr040

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3063989/
https://www.ncbi.nlm.nih.gov/pubmed/21307087
http://dx.doi.org/10.1093/hmg/ddr040

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