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Premature death and neurologic abnormalities in transgenic mice expressing a mutant huntingtin exon-2 fragment
Huntington's disease (HD) is a fatal neurodegenerative disease characterized pathologically by aggregates composed of N-terminal fragments of the mutant form of the protein huntingtin (htt). The role of these N-terminal fragments in disease pathogenesis has been questioned based in part on stud...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3063989/ https://www.ncbi.nlm.nih.gov/pubmed/21307087 http://dx.doi.org/10.1093/hmg/ddr040 |