p38 Mitogen-Activated Protein Kinase-Dependent Transactivation of ErbB Receptor Family: A Novel Common Mechanism for Stress-Induced IRS-1 Serine Phosphorylation and Insulin Resistance

OBJECTIVE: Stress stimuli such as tumor necrosis factor (TNF) have been shown to induce insulin receptor substrate (IRS)-1 serine phosphorylation and insulin resistance by transactivation of ErbB receptors. We aimed at elucidating the potential role of p38 mitogen-activated protein kinase (p38MAPK)...

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Detalles Bibliográficos
Autores principales: Hemi, Rina, Yochananov, Yafit, Barhod, Ehud, Kasher-Meron, Michal, Karasik, Avraham, Tirosh, Amir, Kanety, Hannah
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2011
Materias:
Signal Transduction
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3064087/
https://www.ncbi.nlm.nih.gov/pubmed/21386087
http://dx.doi.org/10.2337/db09-1323

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3064087/
https://www.ncbi.nlm.nih.gov/pubmed/21386087
http://dx.doi.org/10.2337/db09-1323

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