Cargando…

Diet-Induced Adipose Tissue Inflammation and Liver Steatosis Are Prevented by DPP-4 Inhibition in Diabetic Mice

OBJECTIVE: Diet composition alters the metabolic states of adipocytes and hepatocytes in diabetes. The effects of dipeptidyl peptidase-4 (DPP-4) inhibition on adipose tissue inflammation and fatty liver have been obscure. We investigated the extrapancreatic effects of DPP-4 inhibition on visceral fa...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shirakawa, Jun, Fujii, Hideki, Ohnuma, Kei, Sato, Koichiro, Ito, Yuzuru, Kaji, Mitsuyo, Sakamoto, Eri, Koganei, Megumi, Sasaki, Hajime, Nagashima, Yoji, Amo, Kikuko, Aoki, Kazutaka, Morimoto, Chikao, Takeda, Eiji, Terauchi, Yasuo
Formato:	Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2011
Materias:	Pathophysiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3064098/ https://www.ncbi.nlm.nih.gov/pubmed/21330637 http://dx.doi.org/10.2337/db10-1338

Ejemplares similares

DPP-4 inhibition improves early mortality, β cell function, and adipose tissue inflammation in db/db mice fed a diet containing sucrose and linoleic acid
por: Shirakawa, Jun, et al.
Publicado: (2016)

Sitagliptin, a DPP-4 Inhibitor, Acutely Inhibits Intestinal Lipoprotein Particle Secretion in Healthy Humans
por: Xiao, Changting, et al.
Publicado: (2014)

Adipose Tissue Dysfunction Signals Progression of Hepatic Steatosis Towards Nonalcoholic Steatohepatitis in C57Bl/6 Mice
por: Duval, Caroline, et al.
Publicado: (2010)

Cellularity and Adipogenic Profile of the Abdominal Subcutaneous Adipose Tissue From Obese Adolescents: Association With Insulin Resistance and Hepatic Steatosis
por: Kursawe, Romy, et al.
Publicado: (2010)

The beneficial effects of a muscarinic agonist on pancreatic β-cells
por: Ito, Yuzuru, et al.
Publicado: (2019)

Effects of xylitol on metabolic parameters and visceral fat accumulation
por: Amo, Kikuko, et al.
Publicado: (2011)

AMPK Is Involved in the Regulation of Incretin Receptors Expression in Pancreatic Islets under a Low Glucose Concentration
por: Tajima, Kazuki, et al.
Publicado: (2013)

Functional roles of CD26/DPP4 in bleomycin‐induced pulmonary fibrosis
por: Koyanagi, Yu, et al.
Publicado: (2023)

Amylase α-2A Autoantibodies: Novel Marker of Autoimmune Pancreatitis and Fulminant Type 1 Diabetes
por: Endo, Toyoshi, et al.
Publicado: (2009)

Interactions Among Glucose Delivery, Transport, and Phosphorylation That Underlie Skeletal Muscle Insulin Resistance in Obesity and Type 2 Diabetes: Studies With Dynamic PET Imaging
por: Goodpaster, Bret H., et al.
Publicado: (2014)

Dietary combination of sucrose and linoleic acid causes skeletal muscle metabolic abnormalities in Zucker fatty rats through specific modification of fatty acid composition
por: Ohminami, Hirokazu, et al.
Publicado: (2014)

Genetically engineered pigs manifesting pancreatic agenesis with severe diabetes
por: Nagaya, Masaki, et al.
Publicado: (2020)

Identification of senescent cell surface targetable protein DPP4
por: Kim, Kyoung Mi, et al.
Publicado: (2017)

Plasma Fetuin-A Levels and the Risk of Type 2 Diabetes
por: Stefan, Norbert, et al.
Publicado: (2008)

Distinct Monocyte Gene-Expression Profiles in Autoimmune Diabetes
por: Padmos, Roos C., et al.
Publicado: (2008)

Plasma YKL-40: A BMI-Independent Marker of Type 2 Diabetes
por: Nielsen, Anders R., et al.
Publicado: (2008)

Protein Engineering Strategies for Sustained Glucagon-Like Peptide-1 Receptor–Dependent Control of Glucose Homeostasis
por: Picha, Kristen M., et al.
Publicado: (2008)

Circulating Retinol-Binding Protein-4 Concentration Might Reflect Insulin Resistance–Associated Iron Overload
por: Fernández-Real, José Manuel, et al.
Publicado: (2008)

Novel De Novo Mutation in Sulfonylurea Receptor 1 Presenting as Hyperinsulinism in Infancy Followed by Overt Diabetes in Early Adolescence
por: Abdulhadi-Atwan, Maha, et al.
Publicado: (2008)

Effect of Oral Amino Acids on Counterregulatory Responses and Cognitive Function During Insulin-Induced Hypoglycemia in Nondiabetic and Type 1 Diabetic People
por: Rossetti, Paolo, et al.
Publicado: (2008)

Activation of Peroxisome Proliferator–Activated Receptor β/δ Inhibits Lipopolysaccharide-Induced Cytokine Production in Adipocytes by Lowering Nuclear Factor-κB Activity via Extracellular Signal–Related Kinase 1/2
por: Rodríguez-Calvo, Ricardo, et al.
Publicado: (2008)

Altered Calcium Homeostasis Does Not Explain the Contractile Deficit of Diabetic Cardiomyopathy
por: Zhang, Lin, et al.
Publicado: (2008)

Increase in Endoplasmic Reticulum Stress–Related Proteins and Genes in Adipose Tissue of Obese, Insulin-Resistant Individuals
por: Boden, Guenther, et al.
Publicado: (2008)

Evidence for Interindividual Heterogeneity in the Glucose Gradient Across the Human Red Blood Cell Membrane and Its Relationship to Hemoglobin Glycation
por: Khera, Paramjit K., et al.
Publicado: (2008)

Effects of a Selective Serotonin Reuptake Inhibitor, Fluoxetine, on Counterregulatory Responses to Hypoglycemia in Healthy Individuals
por: Briscoe, Vanessa J., et al.
Publicado: (2008)

Portal Vein Glucose Sensors Do Not Play a Major Role in Modulating Physiological Responses to Insulin-Induced Hypoglycemia in Humans
por: Rossetti, Paolo, et al.
Publicado: (2009)

Hepatic Stearoyl-CoA Desaturase (SCD)-1 Activity and Diacylglycerol but Not Ceramide Concentrations Are Increased in the Nonalcoholic Human Fatty Liver
por: Kotronen, Anna, et al.
Publicado: (2009)

Diabetes, Abdominal Adiposity, and Atherogenic Dyslipoproteinemia in Women Compared With Men
por: Williams, Ken, et al.
Publicado: (2008)

Intracellular Angiotensin II Production in Diabetic Rats Is Correlated With Cardiomyocyte Apoptosis, Oxidative Stress, and Cardiac Fibrosis
por: Singh, Vivek P., et al.
Publicado: (2008)

Effect of Endothelium-Specific Insulin Resistance on Endothelial Function In Vivo
por: Duncan, Edward R., et al.
Publicado: (2008)

Effects of the Selective Serotonin Reuptake Inhibitor Fluoxetine on Counterregulatory Responses to Hypoglycemia in Individuals With Type 1 Diabetes
por: Briscoe, Vanessa J., et al.
Publicado: (2008)

Evidence That Kidney Function but Not Type 2 Diabetes Determines Retinol-Binding Protein 4 Serum Levels
por: Henze, Andrea, et al.
Publicado: (2008)

Reduction in Basal Nitric Oxide Activity Causes Albuminuria
por: Ott, Christian, et al.
Publicado: (2011)

Thirty Years of Prospective Nationwide Incidence of Childhood Type 1 Diabetes: The Accelerating Increase by Time Tends to Level Off in Sweden
por: Berhan, Yonas, et al.
Publicado: (2011)

GLUT2 Accumulation in Enterocyte Apical and Intracellular Membranes: A Study in Morbidly Obese Human Subjects and ob/ob and High Fat–Fed Mice
por: Ait-Omar, Amal, et al.
Publicado: (2011)

Skeletal Muscle Triglycerides, Diacylglycerols, and Ceramides in Insulin Resistance: Another Paradox in Endurance-Trained Athletes?
por: Amati, Francesca, et al.
Publicado: (2011)

Impaired Glucose Tolerance in the Absence of Adenosine A1 Receptor Signaling
por: Faulhaber-Walter, Robert, et al.
Publicado: (2011)

Loss of Inverse Relationship Between Pulsatile Insulin and Glucagon Secretion in Patients With Type 2 Diabetes
por: Menge, Björn A., et al.
Publicado: (2011)

The Insulin-Like Growth Factor-1 Receptor Is a Negative Regulator of Nitric Oxide Bioavailability and Insulin Sensitivity in the Endothelium
por: Abbas, Afroze, et al.
Publicado: (2011)

Higher Cord C-Peptide Concentrations Are Associated With Slower Growth Rate in the 1st Year of Life in Girls but Not in Boys
por: Regnault, Nolwenn, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_da786dmtfam94h989bb9c3h3o4