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Disease-associated N-terminal Complement Factor H Mutations Perturb Cofactor and Decay-accelerating Activities

Many mutations associated with atypical hemolytic uremic syndrome (aHUS) lie within complement control protein modules 19–20 at the C terminus of the complement regulator factor H (FH). This region mediates preferential action of FH on self, as opposed to foreign, membranes and surfaces. Hence, spec...

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Detalles Bibliográficos
Autores principales: Pechtl, Isabell C., Kavanagh, David, Mcintosh, Nicola, Harris, Claire L., Barlow, Paul N.
Formato: Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3064162/
https://www.ncbi.nlm.nih.gov/pubmed/21270465
http://dx.doi.org/10.1074/jbc.M110.211839