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Disease-associated N-terminal Complement Factor H Mutations Perturb Cofactor and Decay-accelerating Activities
Many mutations associated with atypical hemolytic uremic syndrome (aHUS) lie within complement control protein modules 19–20 at the C terminus of the complement regulator factor H (FH). This region mediates preferential action of FH on self, as opposed to foreign, membranes and surfaces. Hence, spec...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3064162/ https://www.ncbi.nlm.nih.gov/pubmed/21270465 http://dx.doi.org/10.1074/jbc.M110.211839 |