MMSET regulates histone H4K20 methylation and 53BP1 accumulation at DNA damage sites

p53-binding protein 1 (53BP1) is known to be an important mediator of the DNA-damage response1, with di-methylation of histone H4 lysine 20 (H4K20me2) critical to the recruitment of 53BP1 to double strand breaks (DSBs)2,3. However, it is not clear how 53BP1 is specifically targeted to the sites of D...

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Detalles Bibliográficos
Autores principales: Pei, Huadong, Zhang, Lindsey, Luo, Kuntian, Qin, Yuxin, Chesi, Marta, Fei, Frances, Bergsagel, P. Leif, Wang, Liewei, You, Zhongsheng, Lou, Zhenkun
Formato: Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3064261/
https://www.ncbi.nlm.nih.gov/pubmed/21293379
http://dx.doi.org/10.1038/nature09658

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3064261/
https://www.ncbi.nlm.nih.gov/pubmed/21293379
http://dx.doi.org/10.1038/nature09658

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