Molecular Recognition of H3/H4 Histone Tails by the Tudor Domains of JMJD2A: A Comparative Molecular Dynamics Simulations Study

BACKGROUND: Histone demethylase, JMJD2A, specifically recognizes and binds to methylated lysine residues at histone H3 and H4 tails (especially trimethylated H3K4 (H3K4me3), trimethylated H3K9 (H3K9me3) and di,trimethylated H4K20 (H4K20me2, H4K20me3)) via its tandem tudor domains. Crystal structures...

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Detalles Bibliográficos
Autores principales: Ozboyaci, Musa, Gursoy, Attila, Erman, Burak, Keskin, Ozlem
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3064570/
https://www.ncbi.nlm.nih.gov/pubmed/21464980
http://dx.doi.org/10.1371/journal.pone.0014765

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3064570/
https://www.ncbi.nlm.nih.gov/pubmed/21464980
http://dx.doi.org/10.1371/journal.pone.0014765

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