Mitotic Defects Lead to Pervasive Aneuploidy and Accompany Loss of RB1 Activity in Mouse Lmna(Dhe) Dermal Fibroblasts

BACKGROUND: Lamin A (LMNA) is a component of the nuclear lamina and is mutated in several human diseases, including Emery-Dreifuss muscular dystrophy (EDMD; OMIM ID# 181350) and the premature aging syndrome Hutchinson-Gilford progeria syndrome (HGPS; OMIM ID# 176670). Cells from progeria patients ex...

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Detalles Bibliográficos
Autores principales: Pratt, C. Herbert, Curtain, Michelle, Donahue, Leah Rae, Shopland, Lindsay S.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3064591/
https://www.ncbi.nlm.nih.gov/pubmed/21464947
http://dx.doi.org/10.1371/journal.pone.0018065

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3064591/
https://www.ncbi.nlm.nih.gov/pubmed/21464947
http://dx.doi.org/10.1371/journal.pone.0018065

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