Trans-cleaving hammerhead ribozymes with tertiary stabilizing motifs: in vitro and in vivo activity against a structured viroid RNA

Trans-cleaving hammerheads with discontinuous or extended stem I and with tertiary stabilizing motifs (TSMs) have been tested previously against short RNA substrates in vitro at low Mg(2+) concentration. However, the potential of these ribozymes for targeting longer and structured RNAs in vitro and...

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Detalles Bibliográficos
Autores principales: Carbonell, Alberto, Flores, Ricardo, Gago, Selma
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
RNA
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3064770/
https://www.ncbi.nlm.nih.gov/pubmed/21097888
http://dx.doi.org/10.1093/nar/gkq1051

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3064770/
https://www.ncbi.nlm.nih.gov/pubmed/21097888
http://dx.doi.org/10.1093/nar/gkq1051

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