Epigenetic control of a VDR-governed feed-forward loop that regulates p21((waf1/cip1)) expression and function in non-malignant prostate cells

In non-malignant RWPE-1 prostate epithelial cells signaling by the nuclear receptor Vitamin D Receptor (VDR, NR1I1) induces cell cycle arrest through targets including CDKN1A (encodes p21((waf1/cip1))). VDR dynamically induced individual histone modification patterns at three VDR binding sites (R1,...

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Detalles Bibliográficos
Autores principales: Thorne, James L., Maguire, Orla, Doig, Craig L., Battaglia, Sebastiano, Fehr, Leah, Sucheston, Lara E., Heinaniemi, Merja, O’Neill, Laura P., McCabe, Christopher J., Turner, Bryan M., Carlberg, Carsten, Campbell, Moray J.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
Gene Regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3064804/
https://www.ncbi.nlm.nih.gov/pubmed/21088000
http://dx.doi.org/10.1093/nar/gkq875

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3064804/
https://www.ncbi.nlm.nih.gov/pubmed/21088000
http://dx.doi.org/10.1093/nar/gkq875

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