EMSY overexpression disrupts the BRCA2/RAD51 pathway in the DNA-damage response: implications for chromosomal instability/recombination syndromes as checkpoint diseases

EMSY links the BRCA2 pathway to sporadic breast/ovarian cancer. It encodes a nuclear protein that binds to the BRCA2 N-terminal domain implicated in chromatin/transcription regulation, but when sporadically amplified/overexpressed, increased EMSY level represses BRCA2 transactivation potential and i...

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Detalles Bibliográficos
Autores principales: Cousineau, Isabelle, Belmaaza, Abdellah
Formato: Texto
Lenguaje:English
Publicado: Springer-Verlag 2011
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3064890/
https://www.ncbi.nlm.nih.gov/pubmed/21409565
http://dx.doi.org/10.1007/s00438-011-0612-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3064890/
https://www.ncbi.nlm.nih.gov/pubmed/21409565
http://dx.doi.org/10.1007/s00438-011-0612-5

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