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Branched RNA: A New Architecture for RNA Interference

Branched RNAs with two and four strands were synthesized. These structures were used to obtain branched siRNA. The branched siRNA duplexes had similar inhibitory capacity as those of unmodified siRNA duplexes, as deduced from gene silencing experiments of the TNF-α protein. Branched RNAs are conside...

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Detalles Bibliográficos
Autores principales: Aviñó, Anna, Ocampo, Sandra M., Perales, José Carlos, Eritja, Ramon
Formato: Texto
Lenguaje:English
Publicado: SAGE-Hindawi Access to Research 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3065013/
https://www.ncbi.nlm.nih.gov/pubmed/21461398
http://dx.doi.org/10.4061/2011/586935