Dominant Cone-Rod Dystrophy: A Mouse Model Generated by Gene Targeting of the GCAP1/Guca1a Gene

Cone dystrophy 3 (COD3) is a severe dominantly inherited retinal degeneration caused by missense mutations in GUCA1A, the gene encoding Guanylate Cyclase Activating Protein 1 (GCAP1). The role of GCAP1 in controlling cyclic nucleotide levels in photoreceptors has largely been elucidated using knock-...

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Detalles Bibliográficos
Autores principales: Buch, Prateek K., Mihelec, Marija, Cottrill, Phillippa, Wilkie, Susan E., Pearson, Rachael A., Duran, Yanai, West, Emma L., Michaelides, Michel, Ali, Robin R., Hunt, David M.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3065489/
https://www.ncbi.nlm.nih.gov/pubmed/21464903
http://dx.doi.org/10.1371/journal.pone.0018089

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3065489/
https://www.ncbi.nlm.nih.gov/pubmed/21464903
http://dx.doi.org/10.1371/journal.pone.0018089

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