Calcium Ions Promote Formation of Amyloid β-Peptide (1–40) Oligomers Causally Implicated in Neuronal Toxicity of Alzheimer's Disease

Amyloid β-peptide (Aβ) is directly linked to Alzheimer's disease (AD). In its monomeric form, Aβ aggregates to produce fibrils and a range of oligomers, the latter being the most neurotoxic. Dysregulation of Ca(2+) homeostasis in aging brains and in neurodegenerative disorders plays a crucial r...

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Detalles Bibliográficos
Autores principales: Itkin, Anna, Dupres, Vincent, Dufrêne, Yves F., Bechinger, Burkhard, Ruysschaert, Jean-Marie, Raussens, Vincent
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3065491/
https://www.ncbi.nlm.nih.gov/pubmed/21464905
http://dx.doi.org/10.1371/journal.pone.0018250

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3065491/
https://www.ncbi.nlm.nih.gov/pubmed/21464905
http://dx.doi.org/10.1371/journal.pone.0018250

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